Product Manual (.pdf)

Description

This kit is intended for the quantitative determination of human anti-Müllerian hormone (AMH) levels in serum and lithium heparin plasma samples.

For research use only.

Background

Anti-Müllerian Hormone (AMH) or Müllerian-inhibiting hormone (MIH) is a glycoprotein hormone structurally related to inhibin and activin from the transforming growth factor beta superfamily, whose key roles are in growth differentiation and folliculogenesis. AMH expression is critical to sex differentiation at a specific time during fetal development, and appears to be tightly regulated by nuclear receptor SF1, transcription GATA factors, sex-reversal gene DAX1, and follicle-stimulating hormone (FSH). AMH is activated by SOX9 in the Sertoli cells of the male fetus thereby arresting the development of fallopian tubes, uterus, and upper vagina. AMH is also a product of granulosa cells of the preantral and small antral follicles in women. As such, AMH is only present in the ovary until menopause. AMH
levels are also lower and even below the detection limit if women withpremature ovarian failure of any cause, including after cancer and chemotherapy.

Specifications

Catalog no.

Target:

Species

Method

Tests Per Kit

Detection

Sensitivity / LLOD

Dynamic Range

Total Incubation Time

Sample Type

Sample Volume

Storage Temperature

KTR-804

Human anti-Müllerian hormone

Human

Sandwich ELISA

96 tests

Colorimetric

0.02 ng/mL

0 - 20 ng/mL

4 hours 20 min, shaking,  or overnight, static

Serum, lithium heparin plasma

50 µL

2-8 °C